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Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival. It has ...
Trophoblast cell surface antigen-2 (Trop-2) is a widely expressed glycoprotein on a variety of different tumours. Trop-2 is considered as a marker of germ cells and is associated with regenerative ability in several tissues. Some studies ...
Discover TROP2, a significant protein in cancer biology, and its emerging role as a therapeutic target reshaping oncology treatment strategies.
Despite the marked limitations of this study (inconsistency in Trop-2 assessment and definition of Trop-2 positivity), the authors concluded that a frequent Trop-2 expression in the majority of solid tumors and its association with a poor prognosis provided a good rationale to target Trop-2 for therapeutic purposes [8].
TACSTD2 is a gene that encodes Trop-2, a carcinoma-associated antigen and a cell surface receptor involved in calcium signaling. Trop-2 is overexpressed in several solid cancers and is a target of antibody-drug conjugates.
Trop-2 is a transmembrane glycoprotein that is upregulated in all cancer types independent of baseline levels of Trop-2 expression. Trop-2 is an ideal candidate for targeted therapeutics due to it being a transmembrane protein with an extracellular ...
Trop-2 is a transmembrane glycoprotein highly expressed in various tumors and involved in Ca2+ signaling. This review summarizes the mechanisms, functions and clinical trials of Trop-2-targeted ADCs, a novel and promising anticancer therapy.
Uncover the profound impact of the TROP2 protein on cancer progression and its emerging role as a target for innovative new treatments.
Tumor associated calcium signal transducer 2 Cell surface glycoprotein Trop-2 / Trop2 Gastrointestinal tumor associated antigen GA7331 Pancreatic carcinoma marker protein GA733-1 / GA733 Membrane component chromosome 1 surface marker 1 M1S1 Epithelial glycoprotein 1 (EGP1), CAA1 Gelatinous drop-like corneal dystrophy (GDLD), TTD2 (Genes Cancer ...
Trophoblast cell surface antigen 2 (Trop2) is overexpressed in a range of solid tumors and participants in multiple oncogenic signaling pathways, making it an attractive therapeutic target. In the past decade, the rapid development of various ...