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WNT1 (Wnt Family Member 1) is a Protein Coding gene. Diseases associated with WNT1 include Osteogenesis Imperfecta, Type Xv and Bone Mineral Density Quantitative Trait Locus 16.Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Wnt Pathway.Gene Ontology (GO) annotations related to this gene include signaling receptor binding and transcription cis ...
Proto-oncogene Wnt-1, or Proto-oncogene Int-1 homolog is a protein that in humans is encoded by the WNT1 gene. [5] [6]The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis.
Multiple Wnts including Wnt1, Wnt3a, Wnt5b, Wnt7b, Wnt10b, Wnt11, and Wnt16 regulate osteoblast differentiation and bone formation. 220,252,253,254,255,256 Canonical Wnt signaling promotes ...
WNT1 osteoporosis causes significant skeletal changes already in early childhood and impairs bone mass gain during pubertal years. High WNT1 expression is associated with esophageal squamous cell carcinoma. High WNT1 expression in stromal cells is associated with myelodysplastic syndrome. High WNT1 expression is associated with gastric cancer.
The recent identification of homozygous WNT1 mutations in individuals with osteogenesis imperfecta type XV (OI-XV) has suggested that WNT1 is a key ligand promoting the differentiation and ...
WNT1 mutations in humans are associated with a new form of osteogenesis imperfecta and with early-onset osteoporosis, suggesting a key role of WNT1 in bone mass regulation. However, the general mode of action and the therapeutic potential of Wnt1 in clinically relevant situations such as agin … Wnt1 is an Lrp5-independent bone-anabolic Wnt ...
The Wnt1 gene, originally named Int-1, was identified in 1982 as a gene activated by integration of mouse mammary tumor virus proviral DNA in virally induced breast tumors (Nusse and Varmus, 1982).The Wnt1 proto-oncogene encodes a secreted, cysteine-rich protein. The fly Wingless (wg) gene, which controls segment polarity during larval development (Nüsslein-Volhard and Wieschaus, 1980), was ...
The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not ...
WNT1 mutations in humans are associated with a new form of osteogenesis imperfecta and with early-onset osteoporosis, suggesting a key role of WNT1 in bone mass regulation. However, the general mode of action and the therapeutic potential of Wnt1 in clinically relevant situations such as aging remain to be established.
It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome ...