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In this study, we specifically explored spacer domain residues within region Y658-Y665 that are targeted by antibodies in acquired TTP. Because anti-ADAMTS13 antibodies often directly inhibit ADAMTS13 proteolysis of VWF, we also sought to characterize the role of these residues in ADAMTS13 function. We provide evidence for an interactive surface comprising R660, Y661, and Y665 in the spacer ...
Residues R660, Y661, and Y665 are critical for proteolysis of short VWF substrates, but wider domain interactions also make important contributions to cleavage of full-length VWF.
Antibodies that develop in patients with immune thrombotic thrombocytopenic purpura (iTTP) commonly target the spacer epitope R568/F592/R660/Y661/Y665 (RFRYY). In this study we present a detailed contribution of each residue in this epitope for autoantibody binding. Different panels of mutations wer …
The 1.6-liter Mazda Y6 or 1.6 CiTD engine was produced from 2004 to 2015 in two versions: the first generation units with the Y406, Y601, Y642 and Y646 indices were equipped with a 16-valve cylinder head, and the second generation engines with the Y650, Y655, Y661 and Y6Y1 indices equipped with an 8-valve cylinder head.
In the current issue of Haematologica, Graça and colleagues present a detailed description of the influence of the epitope (R568/F592/R660/Y661/Y665 [RFRYY]), 9 within the spacer domain, the predominant site for autoantibody binding.
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is an autoimmune disorder caused by the development of autoantibodies targeting different domains of ADAMTS13. Profiling studies have shown that residues R568, F592, R660, Y661, and Y665 within exosite-3 of the spacer domain provide an immunodominant region of ADAMTS13 for pathogenic autoantibodies that develop in patients with iTTP ...
The 1.6-liter Mazda Y6 or 1.6 CiTD engine was produced from 2004 to 2015 in two versions: the first generation units with the Y406, Y601, Y642 and Y646 indices were equipped with a 16-valve cylinder head, and the second generation engines with the Y650, Y655, Y661 and Y6Y1 indices equipped with an 8-valve cylinder head. The MZ-CD series also includes diesel: Y4.
The Y661 engine is used by Mazda uses at least the 2. From the data we have collected so far regarding the Y661, it appears that this engine has been used by Mazda in cars from 2010 to 2014.
Residues R660, Y661, and Y665 align very well as a surface exposed cluster, available for ligand interactions (Figure 7). 30, 44 It therefore seems highly likely that there is an important role of these residues as a surface exposed exosite for VWF. Figure 7.
The Seiko Y661-4030 is a watch model based on the Y661 movement. Parts List