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ZFY is a gene that encodes a zinc finger protein involved in transcription and meiotic sex chromosome inactivation. It is located on the Y chromosome and has two splice variants in humans and two paralogs in mice.
Page et al. (1987) identified a Y-encoded zinc finger protein, designated ZFY, which they thought might represent the testis-determining factor (TDF). They cloned a 230-kb segment of the human Y chromosome thought to contain some or all of the TDF gene. The cloned region spanned the deletion in a female who carried all but 160 kb of the Y. Homologous sequences were found within this sex ...
ZFY is a protein coding gene on the Y chromosome that encodes a zinc finger protein. It is involved in male sex determination and has been associated with some disorders and diseases.
ZFY encodes a zinc finger protein that may regulate gene expression. It is involved in some rare disorders such as campomelic dysplasia and Frasier syndrome.
The Y-linked zinc finger gene ZFY is conserved across eutherians and is known to be a critical fertility factor in some species. The initial studies of the mouse homologues, Zfy1 and Zfy2, were performed using mice with spontaneous Y chromosome ...
GeneRIFs: Gene References Into Functions Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility. our findings show that RNAi-mediated disruption of Zfx/Zfy in mouse testis affected X/Y spermatogenesis. Additionally, results suggest that the paralogous genes Zfx/Zfy play an important role in the process of X and Y sperm development. The ...
ZFY is a gene located on the Y chromosome that can be distinguished from the ZFX gene on the X chromosome based on the size of the fragments produced by the restriction enzyme Haelll. From: Textbook of Assisted Reproductive Techniques [2019]
We have cloned and sequenced transcripts from the X- and Y-linked zinc-finger genes ZFX and ZFY respectively and discuss a possible mechanism of post-transcriptional control by which these genes can be widely expressed but translated in only ...
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During male meiosis the X and Y chromosomes pair along much of their length, with a single obligatory recombination event usually occurring in the pseudo-autosomal region (PAR) at the tip of Xp and Yp,1 thus maintaining identity of the sex chromosome PARs.2 Occasionally illegitimate crossover occurs outside the PAR, resulting in the transfer of Y specific sequences onto the X chromosome. Such ...