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CCR2 is a protein that encodes a receptor for monocyte chemoattractant protein-1 (CCL2), a chemokine involved in inflammation and immune response. CCR2 is also associated with Alzheimer's disease, obesity, and bone marrow transplantation.
Chemokines and monocyte trafficking CCR2. CCL2 (also known as MCP1) and CCL7 (also known as MCP3) are CC chemokines that bind to CCR2 and mediate Ly6C Bright monocyte recruitment [].Although expression of CCR2 is restricted to only a few cell types, most (if not all) nucleated cells express CCL2 in response to activation by pro-inflammatory cytokines or stimulation of innate immune receptors ...
CCR2 (C-C Motif Chemokine Receptor 2) is a Protein Coding gene. Diseases associated with CCR2 include Polycystic Lung Disease and Human Immunodeficiency Virus Type 1.Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and chemokine receptor activity.
CCR2 and its ligand CCL2 regulate macrophage recruitment and immune responses in the intestine. This article reviews the current knowledge on CCR2 expression and function in normal and diseased intestine, such as colitis, inflammatory bowel disease, and cancer.
CCR2, a GPCR and key regulator of monocyte migration, was later confirmed as a scavenger receptor (10, 11), and one study showed that CCR2 scavenges more efficiently than the atypical receptor ACKR2 (6, 12). Thus, CCR2 is a dual-function receptor that directly regulates both cell migration and scavenging, in contrast to professional scavenger ...
C-C motif chemokine receptor 2 (CCR2), together with its ligands, especially C-C motif ligand 2 (CCL2), to which CCR2 has the highest affinity, form a noteworthy signaling pathway in recruiting macrophages for the immune responses among variegated disorders in vivo environment. Scientometric methods …
CCR2 is a receptor that attracts monocytes and macrophages in response to CCL2 and other chemokines. It is involved in inflammatory processes in the lung, brain and bone, and blocking it may be a therapeutic strategy for chronic obstructive pulmonary disease.
CCR2-64I gene polymorphism is an important factor for the susceptibility of hepatocellular carcinoma (HCC) but it might not influence the clinical pathological progression of HCC. CCR2-64I is a new risk factor for bladder cancer. CCR2 is important in invasive cancer of the cervix but not in HPV infection or in the development of pre-cancers.
In recent years, CC chemokine receptor 2 (CCR2) has been found to be involved in tumor growth, angiogenesis, epithelial mesenchymal transition, metastasis, and immune escape. CCR2 overexpression ...
CCR2 participates in liver pathology, including acute liver injury, chronic hepatitis, fibrosis/cirrhosis, and tumor progression, by mediating the recruitment of immune cells to inflammation and tumor sites. Although a variety of chemokines have been well studied in various diseases, there is no comprehensive review presenting the roles of all ...