为您找到"
SGLT1
"相关结果约100,000,000个
SGLT1 is a protein that transports glucose and sodium across cell membranes in the intestine and kidney. It is involved in glucose absorption, sodium reabsorption, and diabetes and obesity treatment.
Learn how SGLT2 and SGLT1 inhibitors work to lower blood glucose levels in patients with type 2 diabetes mellitus. Compare the mechanisms, indications, contraindications, and side effects of different SGLT drugs.
SGLT1, the first cloned transporter within the large sodium-solute symporter (SSS) family 2, is a high-affinity, low-capacity glucose transporter with an apparent 2 Na +:1 sugar coupling stoichiometry 2,6.SGLT1 mediates active glucose and galactose absorption in the intestine as well as renal glucose scavenging 4.Mutations in SGLT1 cause glucose-galactose malabsorption (GGM) syndrome 7.
Learn about the family of glucose transporters that use sodium gradients to transport glucose across cell membranes. Find out the functions, structures, and mechanisms of SGLT1, SGLT2, and other members of the SLC5A gene family.
SGLT1 inhibitor is currently being studied and pending Food and Drug Administration (FDA) approval for adults with type 1 diabetes mellitus (T1DM) in combination with insulin therapy. T1DM is a condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood.
SGLT1 conHA is the same as SGLT1 con, except that W660 and G661 of SGLT1 con are reversed to H660 and A661. The uptake buffer contains different combinations of sodium (Na), choline (Ch), or ...
Learn about SGLT1, a protein that transports glucose and sodium across cell membranes, and its role in intestinal and renal glucose absorption. Find chapters and articles on SGLT1 inhibitors, glucose homeostasis, and diabetes management.
On the protein level, human SGLT1 expression has been localized to the apical brush border of the small intestine and the late proximal tubule; SGLT1 protein was also detected in human parotid and submandibular salivary glands, liver, lung, skeletal muscle, heart and pancreatic alpha cells [21, 27, 30, 31].More recently, Vrhovac and colleagues generated and used a novel affinity-purified ...
SGLT1 activity is highly dynamic, with modulation by multiple mechanisms to ensure maximal uptake of carbohydrates (CHOs). Intestinal SGLT1 inhibition lowers and delays the glucose excursion following CHO ingestion and augments glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) secretion. The latter is likely due to increased glucose exposure ...
SGLT1 plays a distinct and complementing role to SGLT2 in glucose homeostasis and, therefore, SGLT1 inhibition may also have therapeutic potential. Areas covered: This review focuses on the physiology of SGLT1 in the small intestine and kidney and its pathophysiological role in diabetes. The therapeutic potential of SGLT1 inhibition, alone as ...