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CCL5 belongs to the CC subfamily of chemokines, due to its adjacent cysteines near N terminus.It is an 8kDa protein acting as a classical chemotactic cytokine or chemokine.It consists of 68 amino acids.CCL5 is proinflammatory chemokine, recruiting leukocytes to the site of inflammation.It is chemotactic for T cells, eosinophils, and basophils, but also for monocytes, natural-killer (NK) cells ...
RANTES (regulated upon activation, normal T cell expressed and secreted [also known as CCL5]) is a model chemokine of relevance to a myriad of diseases. Regulation of RANTES expression is complex. In fibroblasts and monocytes, rel proteins alone suffice to induce transcription of RANTES. By contrast, expression of RANTES in T lymphocytes 3-5 ...
RANTES is a small protein of 68 amino acids and belongs to the rapidly growing chemokine family (for a general review on chemokines, see 1).RANTES induces leukocyte migration by binding to specific receptors in the seven-transmembrane G-protein-coupled receptor (GCPR) family, namely CCR1, CCR3, CCR4 and CCR5 (Fig. 1).It mediates the trafficking and homing of classical lymphoid cells such as T ...
RANTES /CCL5 is a chemotactic factor for monocytes, memory T lymphocytes, NK cells, eosinophils and basophils [6,48]. RA synovial fibroblasts produce RANTES/CCL5 mRNA upon stimulation with TNF-α or IL-1 [29,30]. These effects of TNF-α or IL-1 on RANTES/CCL5 mRNA expression can be further increased by IFN-γ, but suppressed by IL-4 [30].
RANTES is a chemokine molecule that belongs to the CC family and is involved in chemotaxis of monocytes, memory T cells, and eosinophils. It also plays a role in the release of histamine from basophils and activates eosinophils. Additionally, RANTES inhibits M-trophic HIV infection and can form different aggregates with varying biological ...
RANTES (regulated upon activation, normal T cell expressed and secreted [also known as CCL5]) is a model chemokine of relevance to a myriad of diseases. Regulation of RANTES expression is complex.
RANTES has attracted attention because it can potently suppress and, in some circumstances, enhance HIV replication. … The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders.
RANTES, a CC chemokine, plays an important role in the inflammatory response associated with Helicobacter pylori infection. However, the mechanism by which H. pylori induces RANTES expression in the gastric mucosa is unknown. We cocultured gastric epithelial cells with wild-type H. pylori, isogenic oipA mutants, cag pathogenicity island (PAI) mutants, or double knockout mutants.
RANTES (regulated on activation, normal T cell expressed and secreted) is a chemokine implicated in atherosclerosis.Increasing evidence supports the involvement of inflammation in the initiation and progression of atherosclerosis. Chemotactic cytokines or chemokines are small heparin-binding proteins that play a critical role in the inflammatory process by directing the migration of ...
RANTES is a small protein of 68 amino acids and belongs to the rapidly growing chemokine family (for a general review on chemokines, see 1).RANTES induces leukocyte migration by binding to specific receptors in the seven-transmembrane G-protein-coupled receptor (GCPR) family, namely CCR1, CCR3, CCR4 and CCR5 ().It mediates the trafficking and homing of classical lymphoid cells such as T cells ...