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Here, we discuss the current progress and recent advances in the field of TOP2. We specifically focus on the genome biology, microscopy and chromatin landscape studies, and mechanistic investigations to understand the role of TOP2-mediated DNA breaks and their significance in transcription and cancer.
DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene. Topoisomerase IIα relieves topological DNA stress during transcription, condenses chromosomes, and separates chromatids. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another. Two forms of this enzyme exist as likely products of a gene duplication ...
The ability to interfere with topoisomerase II (TOP2) and generate enzyme-mediated DNA damage is an effective strategy for cancer chemotherapy. Can recent studies lead to refined targeting of TOP2 ...
Complete information about the TOP2A gene, including function, proteins, disorders, pathways, orthologs, and expression.
The importance of targeting toposimerase II (TOP2) for the treatment of cancer is not a new concept; however, understanding of the biological functions of this enzyme has lagged behind the use of ...
Type II topoisomerases (TOP2) are conserved regulators of chromatin topology that catalyze reversible DNA double-strand breaks (DSBs) and are essential for maintaining genomic integrity in diverse dynamic processes such as transcription, replication, and cell division. While controlled TOP2-mediated …
Topoisomerase II (TOP2) relieves torsional stress by forming transient cleavage complex intermediates (TOP2ccs) that contain TOP2-linked DNA breaks (DSBs). While TOP2ccs are normally reversible, they can be "trapped" by chemotherapeutic drugs such as etoposide and subsequently converted into irrever …
DNA topoisomerases II (TOP2) are peculiar enzymes (TOP2α and TOP2β) that modulate the conformation of DNA by momentarily breaking double-stranded DNA to allow another strand to pass through, and then rejoins the DNA phosphodiester backbone. TOP2α and TOP2β play vital roles in nearly all events invol …
Results show that topoisomerase II alpha function during late G2 and M-phase is truly required for shaping mitotic chromosomes. Chromosome breakage by TOP2 is an endogenous threat to gene transcription and to normal neuronal development and maintenance.
We show that both TOP2 activity and transcription account for DNA break production following G4 ligand treatments. In contrast, clastogenic activity of these G4 ligands is countered by topoisomerase 1 (TOP1), which limits co-transcriptional G4 formation, and by factors promoting transcriptional elongation.